Table of contents

  • Executive summary
    • Background
    • Dapsone
    • Sites of cancer of a priori interest
    • Design of this study
    • Cancer incidence and dapsone exposure
    • Cancer incidence and Vietnam service
    • Conclusion
  • 1 Introduction
    • 1.1 Background
    • 1.2 Dapsone
    • 1.3 Sites of cancer of a priori interest
    • 1.4 Report structure
  • 2 Aim of the study
  • 3 Data collection, collation and analysis
    • 3.1 Identification of the study cohort
    • 3.2 Identification of servicemen who took dapsone or had malaria
    • 3.3 Identification of servicemen with cancer
    • 3.4 Determination of the population at risk
    • 3.5 Potential risk factors
    • 3.6 Analysis of cancer incidence
  • 4 Cancer incidence in different groups
    • 4.1 Characteristics of the study population
    • 4.2 Dapsone-exposed Vietnam veterans compared with other Vietnam veterans
    • 4.3 Trends in cancer incidence with total dapsone dose
    • 4.4 Vietnam veterans with malaria compared with other veterans
    • 4.5 Cancer incidence among Vietnam veterans compared with non-veterans
    • 4.6 Dapsone-exposed Vietnam veterans compared with non-veterans
    • 4.7 Vietnam conflict era servicemen compared with other Australian males
    • 4.8 Trends in cancer incidence with latency period
  • 5 Cancer incidence for different sites of cancer
    • 5.1 All cancers
    • 5.2 Hodgkin's disease and non-Hodgkin's lymphoma
    • 5.3 Leukemia
    • 5.4 Soft tissue and other sarcomas
    • 5.5 Cancers of the mouth and respiratory system
    • 5.6 Cancers of the digestive system
    • 5.7 Skin melanoma
    • 5.8 Cancers of other organs
    • 5.9 Conclusion
  • 6 Conclusion
  • Appendix A: Protocol for an epidemiological study of cancer in servicemen of the Vietnam era particularly in relation to the use of dapsone
    • A.1 Background
    • A.2 Introduction
    • A.3 Data collection methods
    • A.4 Power of the study
    • A.5 Data analysis
    • A.6 Reporting, privacy and confidentiality
    • Attachment I-Estimating dapsone consumption
    • Attachment II-Sources of data on malaria cases
    • Attachment III-Soundex codes for surnames
  • Appendix B: Matching of service and cancer registration records
    • B.l Procedure for determining which servicemen had had cancer
    • B.2 Effect of exact and partial matching on estimated relative cancer incidence rates
  • Appendix C: Statistical information
    • C.l Calculation of 'expected' numbers of incident cases
    • C.2 Different methods of calculation of the expected number of cancers
    • C.3 Conformation of the data set
    • C.4 Statistical issues
  • Appendix D: Membership  of the Scientific Advisory Committee
  • Appendix E: Project staff
  • Glossary
  • References