Acute kidney injury (AKI) is increasing in incidence globally. This report presents the first national statistical snapshot on AKI and its impact in Australia. The key findings show that AKI accounts for a considerable number of hospitalisations and deaths and further, that the burden of this condition is not equally distributed across the Australian population. These inequalities were seen in relation to all population characteristics examined, namely sex and age, remoteness of residence, socioeconomic disadvantage and Indigenous status.