The Closing the Gap Clearinghouse was established by the Council of Australian Governments (COAG) to bring together evidence-based research on overcoming disadvantage for Indigenous Australians. The Clearinghouse provides access to a collection of information on what works to improve Indigenous people's lives across the building blocks of early childhood and schooling, economic participation, health and safe communities. The Clearinghouse not only collects, but also systematically analyses and synthesises this evidence. This paper provides policy makers with key findings about what works and assesses the gaps in the evidence. It also sets out progress of the Clearinghouse towards its objectives in its first year of operation.