Cancer is a major cause of illness and death in Australia. In 2021 it is estimated that about 151,000 Australians will be diagnosed with cancer (413 per day) and 49,000 will die (135 per day). This report, the latest in a biennial series, presents a comprehensive overview of cancer statistics, including risk factors, screening and other early detection, incidence, treatment, survival, prevalence, mortality, rare cancers, and cancer in Aboriginal and Torres Strait Islander people.