Living with illness or injury (non-fatal burden) caused slightly more total disease burden than dying prematurely (fatal). There has been a moderate shift from fatal to non-fatal burden being the biggest contributor to total burden between 2003 and 2018, driven by less premature deaths.

Significant improvements in fatal burden
Over the 15-year period from 2003 to 2018, and after adjusting for population growth and ageing, there was a 24% decline in fatal burden, with non-fatal burden rates remaining stable. This meant that the total burden decreased by 13%.

Chronic disease and injury cause most of the burden
In 2018, the 5 disease groups that caused the most burden were cancer, musculoskeletal conditions, cardiovascular diseases, mental & substance use disorders and injuries.

Together these disease groups accounted for around two-thirds (65%) of the total burden. With the exception of injuries, which includes acute injuries, these disease groups include mostly chronic, or long-lasting, conditions.
The cancer & other neoplasms disease group contributed the most burden across all years of the study.
Coronary heart disease the leading specific cause of burden
When considering individual diseases, coronary heart disease was the leading cause of burden, and also showed the largest reduction in total burden over time – from 21 to 10 DALY per 1,000 people between 2003 and 2018. This reduction was mainly driven by large declines in fatal burden.
The leading 5 diseases causing burden (% of total DALY) in 2018:
- Coronary heart disease 6.3%
- Back pain & problems 4.5%
- Dementia 4.0%
- Chronic obstructive pulmonary disease (COPD) 3.5%
- Lung cancer 3.2%

ASR = Age-standardised rate.
Notes
- Diseases are presented in descending order, from highest ASR to lowest ASR, with arrows indicating either an increase (red), decrease (blue) or no change (black) in the ASR over time.
- ‘Other musculoskeletal conditions’ are excluded from the rankings.
- There were changes in practices of coding deaths due to dementia; therefore, caution is recommended when interpreting changes over time for dementia burden.
A decline in total burden (based on age-standardised DALY rates) was also seen for stroke, lung and bowel cancer and rheumatoid arthritis. The total burden from dementia increased from 4.5 to 6.1 DALY per 1,000 (partly due to changes in practices of coding deaths due to dementia), and the rank increased from 12 in 2003 to 4 in 2018.
The leading diseases causing fatal burden were coronary heart disease (which had a large decline between 2003 and 2018), lung cancer (slight decline) and suicide & self-inflicted injuries (slight increase). Back pain & problems (which increased slightly between 2003 and 2018) was the leading cause of non-fatal burden, followed by anxiety disorders and depressive disorders (which remained stable).
More burden for males
Males experienced more total burden than females for most age groups. In 2018, males suffered 1.6 times the rate of fatal burden (104 YLL per 1,000 population) experienced by females (65 YLL per 1,000 population). Males suffered almost 3 times the amount of burden due to suicide & self-inflicted injuries (ranked third in males) and more burden from lung cancer than females, while females experienced more burden from dementia (ranked first in females).
Over one-third of disease burden is potentially preventable
In 2018, 38% of the burden of disease could have been prevented by reducing or avoiding exposure to the modifiable risk factors examined in this study.
The risk factors contributing the most burden in 2018 were tobacco use (8.6%), overweight (including obesity) (8.4%), followed by dietary risks (5.4%), high blood pressure (5.1%), and alcohol use (4.5%).

Tobacco use was the leading risk factor for both males and females and contributed the most to fatal burden, with almost 20,500 attributable deaths (13% of all deaths) in 2018. Overweight (including obesity) contributed the most to non-fatal burden.
After adjusting for population growth and ageing, the rates of burden attributable to the top 2 risk factors were shown to decrease over the period 2003 to 2018. For tobacco use, the decline in attributable burden was mainly driven by continued declines in smoking prevalence and major linked diseases. For overweight (including obesity), small declines were evident between 2003 and 2015, followed by a small increase between 2015 and 2018. These trends were partly driven by increasing rates of burden attributable to obesity and some linked diseases such as dementia; and declining rates in burden attributable to overweight (but not obesity) and linked diseases such as cardiovascular diseases.

Declines were observed for most leading risk factors with the exception of illicit drug use for which the age-standardised DALY rate increased by 35% between 2003 and 2018, resulting in change in ranking from the 8th leading risk factor in 2003 to 6th in 2018.
Disease burden is not shared equally across Australia
The overall rate of total, fatal and non-fatal burden was similar across states and territories, except the Northern Territory where the age-standardised DALY rate was 1.4 times as high as the national rate. The Northern Territory has the smallest population, but also a younger population and a higher proportion identifying as Aboriginal or Torres Strait Islander than in other states and territories.

Large inequalities were also found across socioeconomic groups and remoteness areas. The total burden (DALY rate) in: