New (and emerging) psychoactive substances

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New (and emerging) psychoactive substances (NPS) may be defined as substances, whether in a pure form or preparation, where most are not controlled by international drug control conventions but which may pose a public health threat (UNODC 2022). NPS often mimic the effects of existing illicit substances (AIHW 2020). There are several main types of NPS, including:

  • Synthetic cannabinoids – designed to mimic or produce similar effects to cannabis. 
  • Phenethylamines – a class of drugs with psychoactive and stimulant effects and includes amphetamine, methamphetamine and MDMA (ecstasy). NPS phenethylamines include the ‘2C series’, the NBOMe series, PMMA and benzodifurans.
  • Tryptamines – psychoactive hallucinogens found in plants, fungi and animals.
  • Piperazines – typically described as ‘failed pharmaceuticals’ and are frequently sold as ecstasy due to their central nervous system stimulant properties.
  • Synthetic cathinones – have an amphetamine-type analogue including mephedrone (‘meow meow’) and methylone.
  • Novel benzodiazepines – often do not belong to a precise category and are grouped into “other substances”. They have sedative and hypnotic effects, varying dosages of active ingredients and contain contaminants, including highly potent synthetic opioids (UNODC 2022).
  • Other names given to this group of drugs include research chemicals, analogues, legal highs, herbal highs, bath salts, novel psychoactive substances and synthetic drugs (NDARC 2016).


From 2009–2021, NPS have been reported in 134 countries and territories in all regions of the world. Over 1,100 substances have been reported to the United Nations Office on Drugs and Crime (UNODC) Early Warning Advisory, by Governments, laboratories and partner organisations (UNODC 2022).

The number of NPS found globally has been stabilising in recent years – 548 substances in 2020, with 77 of these newly identified psychoactive substances; a year later the number of NPS identified for the first time fell to 50 (UNODC 2022).

In Australia, the NPS market is highly dynamic with fluctuations in the types of NPS available (Sutherland et al. 2020).

The Australian Criminal Intelligence Commission (ACIC) collects national illicit drug seizure data annually from federal, state and territory police services, including the number and weight of seizures to inform the Illicit Drug Data Report (IDDR). According to the latest IDDR:

  • An increase of 6% in the number of NPS border detections, from 575 in 2018–19 to 609 in 2019–20.
  • By number, amphetamine-type substances and cathinone-type substances each accounted for 50% of the total number of analysed seizures made and examined by the Australian Federal Police. There were no seizures of synthetic cannabinoids, tryptamine-type substances or other NPS in 2019–20.
  • By weight, amphetamine-type substances accounted for 82% of the weight of analysed NPS seizures in 2019–20. Cathinone-type substances accounted for 19% of the weight of analysed NPS seizures (ACIC 2021a).


Synthetic cannabinoids

The use of synthetic cannabinoids in Australia is low.

  • The 2019 National Drug Strategy Household Survey (NDSHS) showed that although lifetime use of synthetic cannabinoids doubled between 2013 and 2019 (from 1.3% to 2.6%), recent use dropped dramatically from 1.2% to 0.2% (Figure NPS1).
  • People who regularly use ecstasy and other stimulants interviewed as part of the Ecstasy and Related Drugs Reporting System (EDRS) reported infrequent use of synthetic cannabinoids in 2022, with 1% of the sample reporting use in the past 6 months (Sutherland et al. 2022, Table 17).
  • The low reported use of synthetic cannabinoids has been attributed to the fact that these synthetic cannabinoids do not produce the kinds of effects that people are seeking.
  • The National Wastewater Drug Monitoring Program (NWDMP) ceased monitoring the synthetic cannabinoids JWH-018 and JWH-073 from October 2017. These NPS had not been detected since monitoring commenced in August 2016 (ACIC 2018).

Other NPS

The use of other NPS among the Australian general population is similarly low.

  • The 2019 NDSHS showed that between 2016 and 2019 there were significant decreases in the lifetime and recent use of other psychoactive substances (from 1.0% to 0.7% for lifetime use; and from 0.3% to 0.1% for recent use) (tables S2.31 and S2.32) (AIHW 2020, tables 4.2 and 4.6; Figure NPS1). The estimate for recent use of other psychoactive substances has a relative standard error of 25% to 50% and should be used with caution.
  • Methylone and mephedrone (synthetic stimulants) were previously included in the National Wastewater Drug Monitoring Program (NWDMP) as examples of NPS. However, due to low levels of detection, they were replaced by ketamine from December 2020.  

The population-weighted average consumption of ketamine has fluctuated since its introduction to the program in December 2020. Between August and December 2022:

  • Higher levels of consumption were reported in capital city sites than regional sites.
  • Ketamine consumption increased in both capital cities and regional areas (ACIC 2023).

In 2021, the EDRS changed reporting of NPS to allow for comparability across different reporting methods. From 2021, the EDRS will report recent 6 month use of any NPS as ‘including plant based NPS’ and ‘excluding plant based NPS’.

In 2022, EDRS participants reporting recent 6 month use of:

  • Any NPS, including plant-based, decreased from 16%, to 11% in 2022. This is the lowest percentage of participants reported since monitoring started.
  • Any NPS, excluding plant-based, decreased to 9% in 2022, from 14% in 2021 (Sutherland et al. 2022, Table 16).
  • Ketamine remained stable, 49% of participants in 2022 relative to 2021 (52%)  (Sutherland et al 2022a).

Figure NPS1: Lifetimeᵃ and recentᵇ use of synthetic cannabinoids or other new and emerging psychoactive substances, people aged 14 and over, 2013 to 2019 (percent)

The figure shows the proportion of people aged 14 and over who recently used synthetic cannabis and new and emerging psychoactive substances in 2013, 2016 and 2019. Recent use of both synthetic cannabis and new and emerging psychoactive substances declined between 2013 and 2019 (from 1.2% to 0.2% and 0.4% to 0.1%, respectively).

View data tables >


NPS comprises a category of substances that are fast-evolving, often diversified and typically volatile and may pose a threat to public health (UNODC 2022).

The use of NPS has been linked to health problems, including (but not limited to):

  • cardiovascular problems
  • memory and cognitive impairment
  • psychiatric problems
  • aggression and acute psychosis
  • breathing difficulties
  • fatigue
  • headaches
  • nausea and persistent vomiting
  • abnormally fast heartbeat (tachycardia)
  • seizures
  • tolerance and dependence (ACIC 2019; NSW Ministry of Health 2017; UNODC 2015).

Policy context

The laws surrounding NPS are complex and vary between Australian jurisdictions.

  • To deal with the rapid growth of NPS, some Australian jurisdictions such as New South Wales have implemented blanket bans on selling any substance that has a psychoactive effect (exempting alcohol, tobacco and food).
  • In other jurisdictions, such as Western Australia, specific NPS are banned with additional substances regularly added to the list.
  • Commonwealth legislation also bans any psychoactive substance not covered by legislation elsewhere (NDARC 2016).